Figure 2.
Effect of Kvβ1.2 on the inactivation kinetics of heterologously expressed K+ currents. Inactivation time course of the K+ currents expressed in Shaker (○) or Shaker+β (•)-transfected cells (A) and in Kv4.2 (○) or Kv4.2+β (•)-transfected cells (B). The inactivation time course was best fit to a biexponential function, and the time-constants obtained (τ1 and τ2) are plotted as a function of the membrane potential. Each point represents the mean ± SEM of 6–15 cells. The P values obtained by (M)ANOVA were 0.02 (τ1) and 0.054 (τ2) in A, and 0.415 (τ1) and 0.102 (τ2) in B. Representative traces of 90 ms normalized currents and fits obtained at +40 mV for each group are also shown.
