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. 1999 Jun 1;113(6):897–907. doi: 10.1085/jgp.113.6.897

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Effect of hypoxia on the endogenous and heterologous currents. (A) Current records elicited by pulses to +40 mV for each of the subunit combinations studied. The traces were obtained in control conditions (C), during the application of a N₂-equilibrated solution for 3–5 min (H), and after returning to the control solution (R). (B) Peak amplitudes of Kv4.2 + β currents obtained by depolarizing steps to three potentials applied every 5 s plotted against time. During the indicated periods, the cell was exposed to a N₂-equilibrated solution. (C) Voltage dependence of the hypoxia-induced inhibition of the current amplitude, represented as the percentage of inhibition of the K⁺ current. Each point is the mean ± SEM of 8–29 cells.