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. 1999 Jun 1;113(6):897–907. doi: 10.1085/jgp.113.6.897

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Effect of hypoxia on excised patches from Kv4.2+β-transfected cells. (A) K⁺ currents from a macropatch in the outside-out configuration were obtained with depolarizing pulses with the protocol described in materials and methods applied to the patch every 10 s. The figure represents a peak current versus time plot in which each point is the average of three of the depolarizing pulses. In this cell, hypoxia produced a 19% reduction of the current amplitude. The inset shows the average current traces corresponding to the indicated points, during control (1), hypoxia (2), and washout applications (3). (B) Averaged data of the current amplitude during hypoxic application and after returning to the normoxic solution in six different patches. Both current amplitudes were normalized to the peak current amplitude in control conditions. *P < 0.02.