Table 4.
In vitro activity of coordination complexes and the free 4-aminoquinoline ligands in chloroquine-sensitive (D10) and chloroquine-resistant (K1) strains of P. falciparum.
| Compound | D10 (CQ sensitive) | K1 (CQ resistant) |
|---|---|---|
| IC50(nM) | IC50 (nM) | |
| L1 | 37.10 | 570.0 |
| [Au(L1)(PPh3)]NO3 | 21.09 | 61.53 |
| [Au(C6F5)(L1)] | 18.07 | 61.09 |
| [Rh(Cl)(COD)(L1)] | 21.50 | 81.31 |
|
| ||
| L2 | 16.30 | 4.96 |
| [Au(L2)(PPh3)]NO3 | 10.50 | 5.68 |
| [Au(C6F5)(L2)] | 10.08 | 3.96 |
| [Rh(Cl)(COD)(L2)] | 15.80 | 10.55 |
|
| ||
| L3 | 11.30 | 12.56 |
| [Au(L3)(PPh3)]NO3 | 33.27 | 33.89 |
| [Au(C6F5)(L3)] | 13.70 | 14.65 |
| [Rh(Cl)(COD)(L3)] | 202.00 | 597.59 |
|
| ||
| L4 | 16.54 | 15.54 |
| [Au(L4)(PPh3)]NO3 | 30.32 | 31.09 |
| [Au(C6F5)(L4)] | 23.36 | 12.92 |
| [Rh(Cl)(COD)(L4)] | 56.10 | 47.70 |