Table 3.
Single nucleotide polymorphisms (SNPs) used for the association study, their allele frequencies in 49 aggressive cases and 49 control dogs, and results of chi-square tests for comparisons of case and control allele frequencies
| SNP namea | Chromosomal location | Chromosomal position (Mb)b | Minor allele frequency in controls | Corresponding allele frequency in cases | χ2 | P-value |
|---|---|---|---|---|---|---|
| BICF2P546848 | 2 | 51.80 | 0.29 | 0.30 | 0.044 | 0.83 |
| BICF2P1051894 | 2 | 51.96 | 0.073 | 0.028 | 1.6 | 0.21 |
| BICF2P1398268 | 2 | 52.01 | 0.33 | 0.33 | 0.011 | 0.92 |
| BICF2S23127755 | 2 | 52.14 | 0.23 | 0.21 | 0.078 | 0.78 |
| BICF2P1200391 | 2 | 52.22 | 0.30 | 0.33 | 0.21 | 0.64 |
| BICF2P590055 | 2 | 52.35 | 0.24 | 0.27 | 0.19 | 0.66 |
| BICF2S22939125 | 2 | 52.44 | 0.48 | 0.53 | 0.54 | 0.46 |
| BICF2S23215863 | 2 | 52.48 | 0.30 | 0.31 | 0.025 | 0.87 |
| BICF2P25993 | 2 | 52.73 | 0.49 | 0.45 | 0.19 | 0.66 |
| BICF2S23442706 | 2 | 52.76 | 0.19 | 0.28 | 1.8 | 0.18 |
| Htr1A | 2 | 52.88–52.88 | – | – | – | – |
| BICF2P519607 | 2 | 53.22 | 0.27 | 0.24 | 0.17 | 0.68 |
| BICF2P1341930 | 2 | 53.62 | 0.49 | 0.54 | 0.52 | 0.47 |
| BICF2P1159241 | 12 | 41.11 | 0.12 | 0.13 | 0.012 | 0.91 |
| BICF2P555130 | 12 | 41.59 | 0.13 | 0.21 | 2.1 | 0.15 |
| BICF2S23326229 | 12 | 41.63 | 0.24 | 0.32 | 1.3 | 0.25 |
| Htr1B | 12 | 41.65–41.66 | – | – | – | |
| BICF2P670331 | 12 | 41.80 | 0.15 | 0.23 | 2.2 | 0.14 |
| BICF2S23153760 | 12 | 41.84 | 0.039 | 0.12 | 3.2 | 0.073 |
| BICF2P1426522 | 12 | 42.29 | 0.12 | 0.12 | 0.013 | 0.91 |
| BICF2P27571 | 12 | 42.34 | 0.12 | 0.10 | 0.21 | 0.65 |
| BICF2S23444066 | 12 | 42.39 | 0.12 | 0.11 | 0.032 | 0.86 |
| TIGRP2P164447_rs8805986 | 12 | 42.51 | 0.038 | 0.12 | 3.6 | 0.059 |
| BICF2P812153 | 12 | 42.57 | 0.033 | 0.12 | 4.8 | 0.029 |
| BICF2P855402 | 12 | 42.62 | 0.021 | 0.12 | 6.9 | 0.0086 |
| BICF2G630315581 | 22 | 6.383 | 0.10 | 0.14 | 0.83 | 0.36 |
| BICF2G630315746 | 22 | 6.611 | 0.10 | 0.14 | 0.45 | 0.50 |
| BICF2P1168502 | 22 | 6.973 | 0.10 | 0.11 | 0.0020 | 0.96 |
| Htr2A | 22 | 7.395–7.453 | – | – | – | – |
| BICF2P164280 | 22 | 7.509 | 0.43 | 0.54 | 2.0 | 0.16 |
| BICF2G630316047 | 22 | 7.709 | 0.44 | 0.53 | 1.7 | 0.19 |
| BICF2S23125159 | 22 | 7.866 | 0.19 | 0.21 | 0.047 | 0.83 |
| BICF2S23661838 | 22 | 8.207 | 0.31 | 0.36 | 0.59 | 0.44 |
| BICF2S22954191 | 22 | 8.470 | 0.23 | 0.27 | 0.35 | 0.55 |
| BICF2P813837 | 9 | 46.93 | 0.39 | 0.30 | 1.5 | 0.22 |
| BICF2S23018060 | 9 | 47.06 | 0.33 | 0.37 | 0.22 | 0.64 |
| BICF2S23551918 | 9 | 47.46 | 0.34 | 0.38 | 0.24 | 0.62 |
| Slc6A4 | 9 | 47.55–47.57 | – | |||
| BICF2S23325050 | 9 | 47.64 | 0.11 | 0.15 | 0.53 | 0.47 |
| BICF2S23124809 | 9 | 47.79 | 0.18 | 0.22 | 0.38 | 0.54 |
| BICF2P950384 | 9 | 47.88 | 0.11 | 0.12 | 0.032 | 0.86 |
| BICF2S245135 | 9 | 48.02 | 0.27 | 0.25 | 0.074 | 0.79 |
| BICF2S2347312 | 9 | 48.09 | 0.22 | 0.28 | 0.84 | 0.36 |
| BICF2S23154457 | 9 | 48.13 | 0.31 | 0.24 | 1.2 | 0.28 |
| BICF2S23141984 | 9 | 48.26 | 0.36 | 0.36 | 0.0070 | 0.93 |
ahtr1A, htr1B, htr2A = respectively serotonin receptor 1A, 1B, and 2A gene; slc6A4 = serotonin transporter gene. The genes are included in the table to show their position relative to the SNPs
bSNP positions are based on the second version of the dog genome assembly, released in May 2005 (CanFam2.0) as can be viewed on http://www.broad.mit.edu/ftp/pub/papers/dog_genome/snps_canfam2/
Positions of the genes are based on the second version of the dog genome assembly (CanFam2.0) as displayed in NCBI Map Viewer for Canis familiarishttp://www.ncbi.nlm.nih.gov/mapview/map_search.cgi?taxid=9615