Table 4.
The effects of the studied genotypes (htr1A) or haplotypes (htr1B, htr2A, and slc6A4) on owner impressions of human-directed aggression and dog-directed aggression in 320 dogs
| Genotype or haplotype classa | Number of animals | Effect relative to class ‘unknown’ | |
|---|---|---|---|
| Human-directed aggression | Dog-directed aggression | ||
| htr1A | |||
| Unknown | 44 | 0.00 | 0.00 |
| 297/297 | 74 | 0.028 | 0.11 |
| 297/303 | 111 | 0.24 | 0.054 |
| 297/305 | 15 | 0.012 | 0.089 |
| 303/303 | 62 | 0.18 | 0.085 |
| 303/305 | 10 | −0.11 | −0.067 |
| Other | 4 | −0.046 | −0.17 |
| htr1B | |||
| Unknown | 166 | 0.00 | 0.00 |
| 143-A-G-T-G/143-A-G-T-G | 20 | −0.73 | 0.28 |
| 143-A-G-T-G /143-C-A-T-G | 8 | −0.63 | −0.19 |
| 143-A-G-T-G /139-A-G-C-C | 19 | 0.11 | 0.19 |
| 143-C-A-T-G/143-C-A-T-G | 41 | −0.17 | 0.13 |
| 143-C-A-T-G /143-A-G-C-C | 10 | −0.021 | 0.059 |
| 143-C-A-T-G /139-A-G-C-C | 30 | 0.0006 | 0.32 |
| 139-A-G-C-C/139-A-G-C-C | 9 | 0.24 | 0.11 |
| Other | 17 | 0.15 | 0.36 |
| htr2A | |||
| Unknown | 114 | 0.00 | 0.00 |
| 132-C/132-C | 40 | −0.15 | −0.19 |
| 132-C/130-C | 60 | −0.27 | −0.023 |
| 132-C/132-T | 28 | −0.22 | 0.073 |
| 132-C/128-C | 15 | −0.38 | −0.43 |
| 130-C/130-C | 21 | −0.33 | −0.072 |
| 130-C/132-T | 22 | 0.10 | −0.19 |
| 130-C/128-C | 9 | −0.52 | −0.29 |
| Other | 11 | 0.33 | −0.036 |
| slc6A4 | |||
| Unknown | 103 | 0.00 | 0.00 |
| C-G/C-G | 116 | 0.025 | −0.23 |
| C-G/T-A | 94 | 0.14 | −0.23 |
| Other | 7 | 0.079 | −0.10 |
None of the effects was significant
aNote that there are additional alleles compared to Table 1 as a result of the larger study group. The htr1A class “other” contains genotypes 295/297 (n = 2 dogs) and 305/305 (n = 1 dog). For htr1B, the class “other” contains haplotypes 143-A-G-T-G/143-A-G-C-C (n = 3 dogs), 143-A-G-T-G/139-A-G-T-G (n = 1 dog), 143-A-G-T-G/147-A-G-T-G (n = 2 dogs), 143-A-G-C-C /139-A-G-C-C (n = 3 dogs), 143-A-G-C-C/147-A-G-T-G (n = 1 dog), 139-A-G-C-C /139-A-G-T-G (n = 3 dogs), and 143-C-A-T-G/139-A-G-T-G (n = 4 dogs). For htr2A, “other” contains haplotypes 0/130-C (n = 2 dogs), 0/132-T (n = 1 dog), 132-T /132-T (n = 6 dogs), and 132-T/128-C (n = 2 dogs). For slc6A4, “other” contains C-G/T-G (n = 1 dog) and T-A/T-A (n = 6 dogs). Unknown genotypes and haplotypes are the result of failure of genotyping or of the absence of a DNA sample (n = 44 dogs)