TABLE 1.
Group | Schedule* | # Patients | Peptides† | Dose (mg) | # Vaccinations Received‡ |
---|---|---|---|---|---|
1 | qw × 4, q7w × 2 | 5 | Class I | 1 | 4, 4, 16, 8, 4 |
2 | q3w × 4 | 7 | Class I | 1 | 2, 4, 4, 8, 2, 4, 4 |
3 | qd × 4, q3w × 4 | 7 | Class I | 1 | 8, 2, 4, 3, 2, 4, 2 |
4 | q3w × 4 | 12§¶ | Both | 1 + 4 | 8, 2, 4, 6, 4, 2, 2, 2, 2, 4 |
5 | q3w × 4 | 6§ | Class II | 4 | 8, 2, 2, 4, 2 |
Schedule per course of treatment.
Class I peptide, ESO-1:165V; class II peptide, ESO-1:161-180.
One vaccination is defined as one peptide injection, except for the daily-times-four schedule, where four consecutive daily peptide injections make up one vaccination.
One patient was censored from final immunologic analysis for having received only one vaccination.
One patient was censored from final immunologic analysis because of incorrect HLA-A2 subtype.