Figure 6. .
Impact of GRIK2 mutation on GLUK6 protein structure. Shown is a schematic representation of the GRIK2 wild-type allele and a cartoon of a GLUK6 monomer. MI–MIII = transmembrane domains; P = pore loop. Letters indicate the start and end of different alterations in the genomic sequence and their corresponding impact on the resulting protein. a = deletion of exons 7 and 8; b = complete genomic rearrangement, as observed in patients with MR; c = region lacking in the putative transcript with a junction between exons 6 and 14.