Table 4.
Results of pathway profiling using Pathway Express.
| Rank | Database Name | Pathway Name | Impact Factor | #Genes in Pathway | #Input Genes in Pathway | #Pathway Genes on Chip | %Input Genes in Pathway | %Pathway Genes in Input | p-value |
| 1 | KEGG | Cell adhesion molecules (CAMs) | 6.94 | 132 | 11 | 126 | 2.099 | 8.333 | 9.69E-04 |
| 2 | KEGG | Axon guidance | 6.94 | 130 | 11 | 126 | 2.099 | 8.462 | 9.69E-04 |
| 3 | KEGG | Leukocyte transendothelial migration | 5.288 | 117 | 9 | 113 | 1.718 | 7.692 | 0.005054 |
| 4 | KEGG | Type I diabetes mellitus | 5.232 | 44 | 5 | 40 | 0.954 | 11.364 | 0.005344 |
| 5 | KEGG | Regulation of actin cytoskeleton | 4.461 | 206 | 12 | 198 | 2.29 | 5.825 | 0.011556 |
| 6 | KEGG | Natural killer cell mediated cytotoxicity | 4.11 | 128 | 8 | 114 | 1.527 | 6.25 | 0.016401 |
| 7 | KEGG | Focal adhesion | 3.949 | 194 | 11 | 188 | 2.099 | 5.67 | 0.019276 |
| 8 | KEGG | Tight junction | 3.187 | 119 | 7 | 112 | 1.336 | 5.882 | 0.041314 |
| 9 | KEGG | Antigen processing and presentation | 3.112 | 86 | 5 | 68 | 0.954 | 5.814 | 0.044499 |
| 10 | KEGG | Adherens junction | 2.721 | 77 | 5 | 76 | 0.954 | 6.494 | 0.065823 |
| 11 | KEGG | Colorectal cancer | 2.676 | 77 | 5 | 77 | 0.954 | 6.494 | 0.068828 |
| 12 | KEGG | Circadian rhythm | 2.386 | 18 | 2 | 18 | 0.382 | 11.111 | 0.091979 |
| 13 | KEGG | Maturity onset diabetes of the young | 1.975 | 25 | 2 | 23 | 0.382 | 8 | 0.138816 |
| 14 | KEGG | VEGF signaling pathway | 1.972 | 72 | 4 | 70 | 0.763 | 5.556 | 0.139208 |
| 15 | KEGG | Fc epsilon RI signaling pathway | 1.83 | 75 | 4 | 74 | 0.763 | 5.333 | 0.160493 |
| 16 | KEGG | mTOR signaling pathway | 1.811 | 49 | 3 | 49 | 0.573 | 6.122 | 0.16353 |
| 17 | KEGG | Huntington's disease | 1.558 | 30 | 2 | 30 | 0.382 | 6.667 | 0.210455 |
| 18 | KEGG | Wnt signaling pathway | 1.474 | 147 | 6 | 144 | 1.145 | 4.082 | 0.229071 |
| 19 | KEGG | MAPK signaling pathway | 1.441 | 273 | 10 | 268 | 1.908 | 3.663 | 0.236637 |
| 20 | KEGG | Toll-like receptor signaling pathway | 1.416 | 91 | 4 | 88 | 0.763 | 4.396 | 0.242667 |
| 21 | KEGG | B cell receptor signaling pathway | 1.318 | 63 | 3 | 63 | 0.573 | 4.762 | 0.267565 |
| 22 | KEGG | T cell receptor signaling pathway | 1.294 | 93 | 4 | 93 | 0.763 | 4.301 | 0.274064 |
| 23 | KEGG | Long-term potentiation | 1.235 | 67 | 3 | 66 | 0.573 | 4.478 | 0.290928 |
| 24 | KEGG | Insulin signaling pathway | 1.143 | 135 | 5 | 131 | 0.954 | 3.704 | 0.318761 |
| 25 | KEGG | Type II diabetes mellitus | 1.117 | 44 | 2 | 41 | 0.382 | 4.545 | 0.327167 |
| 26 | KEGG | Dentatorubropallidoluysian atrophy (DRPLA) | 1.044 | 15 | 1 | 15 | 0.191 | 6.667 | 0.352194 |
| 27 | KEGG | Epithelial cell signaling in Helicobacter pylori infection | 0.997 | 46 | 2 | 45 | 0.382 | 4.348 | 0.368822 |
| 28 | KEGG | Parkinson's disease | 0.992 | 16 | 1 | 16 | 0.191 | 6.25 | 0.370684 |
| 29 | KEGG | Cytokine-cytokine receptor interaction | 0.963 | 256 | 8 | 241 | 1.527 | 3.125 | 0.381922 |
| 30 | KEGG | Jak-STAT signaling pathway | 0.936 | 153 | 5 | 144 | 0.954 | 3.268 | 0.392344 |
| 31 | KEGG | Apoptosis | 0.86 | 84 | 3 | 83 | 0.573 | 3.571 | 0.423249 |
| 32 | KEGG | Complement and coagulation cascades | 0.6 | 69 | 2 | 64 | 0.382 | 2.899 | 0.548544 |
| 33 | KEGG | Olfactory transduction | 0.523 | 31 | 1 | 31 | 0.191 | 3.226 | 0.592482 |
| 34 | KEGG | SNARE interactions in vesicular transport | 0.468 | 36 | 1 | 34 | 0.191 | 2.778 | 0.62642 |
| 35 | KEGG | Phosphatidylinositol signaling system | 0.421 | 79 | 2 | 78 | 0.382 | 2.532 | 0.656227 |
| 36 | KEGG | Taste transduction | 0.317 | 53 | 1 | 45 | 0.191 | 1.887 | 0.728441 |
| 37 | KEGG | GnRH signaling pathway | 0.277 | 97 | 2 | 95 | 0.382 | 2.062 | 0.758254 |
| 38 | KEGG | Gap junction | 0.27 | 99 | 2 | 96 | 0.382 | 2.02 | 0.763352 |
| 39 | KEGG | Adipocytokine signaling pathway | 0.145 | 69 | 1 | 69 | 0.191 | 1.449 | 0.864684 |
| 40 | KEGG | Long-term depression | 0.124 | 75 | 1 | 74 | 0.191 | 1.333 | 0.882976 |
| 41 | KEGG | Neuroactive ligand-receptor interaction | 0.102 | 302 | 5 | 279 | 0.954 | 1.656 | 0.902917 |
| 42 | KEGG | ECM-receptor interaction | 0.086 | 87 | 1 | 86 | 0.191 | 1.149 | 0.91743 |
| 43 | KEGG | Cell cycle | 0.042 | 112 | 1 | 110 | 0.191 | 0.893 | 0.958921 |
| 44 | KEGG | Calcium signaling pathway | 0.041 | 176 | 2 | 173 | 0.382 | 1.136 | 0.959904 |