Figure 1.

Structural map of human dnmt1. The structure of the human CpG MTase dnmt1 is shown schematically at the cDNA level. The numbering of nucleotide sequences (1–5,387) follows that used in ref. 8. Besides the initiation and termination codons, the locations of the cDNA regions coding for the PCNA-binding domain, the nuclear localization signal, and the replication foci-targeting sequence are also indicated. The site of insertion of the 48-bp Alu repeat segment through alternative splicing is also marked with a black triangle. It is between nucleotides 682 and 683. UTR, untranslated region.