TABLE 2.
Baseline hemodynamic parameters in CB2−/− and CB2 +/+ mice measured by Millar pressure-volume conductance catheter system
| CB2+/+ | CB2−/− | P1 | |
|---|---|---|---|
| HR (beat/min) | 473.1 ± 14.4 | 475.3 ± 10.5 | 0.50 |
| MAP (mmHg) | 89.1 ± 3.5 | 86.4 ± 2.0 | 0.69 |
| LVESP (mmHg) | 102.4 ± 4.0 | 98.9 ± 1.8 | 0.68 |
| LVEDP (mmHg) | 4.0 ± 1.4 | 2.8 ± 0.7 | 0.52 |
| CO (ml/min) | 13.1 ± 0.5 | 12.6 ± 0.6 | 0.64 |
| Stroke volume (μl) | 27.7 ± 0.4 | 26.7 ± 0.6 | 0.51 |
| EF (%) | 59.6 ± 3.6 | 59.4 ± 2.4 | 0.53 |
| SW (mmHg. μl) | 2426.0 ± 65.9 | 2267.0 ± 144.7 | 0.68 |
| +dP/dt (mmHg/s) | 8819.9 ± 661.9 | 9065.2 ± 377.0 | 0.28 |
| −dP/dt (mmHg/s) | 6796.1 ± 322.4 | 7095.9 ± 376.0 | 0.27 |
| τ (Weiss; ms) | 7.2 ± 0.4 | 6.6 ± 0.2 | 0.22 |
| τ (Glantz; ms) | 11.4 ± 0.6 | 10.5 ± 0.1 | 0.13 |
| TPR mmHg·ml−1·min | 6.9 ± 0.4 | 7.0 ± 0.4 | 0.73 |
Values are mean ± sem of 7 to 8 experiments. HR, heart rate; MAP, mean arterial pressure; LVESP, left ventricular end-systolic pressure; LVEDP, left ventricular end-diastolic pressure; CO, cardiac output; EF, ejection fraction; SW, stroke work; +dP/dt, systolic pressure increment; −dP/dt, diastolic pressure decrement; τ, relaxation time constant; TPR, total peripheral resistance.