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. Author manuscript; available in PMC: 2008 Feb 4.
Published in final edited form as: Antioxid Redox Signal. 2005;7(11-12):1568–1580. doi: 10.1089/ars.2005.7.1568

FIG. 1. Reactive nitrogen species generation, DNA breakage, and PARP activation in diabetic blood vessels.

FIG. 1

(a–c) Immunohistochemical staining for nitrotyrosine in control rings (a), in rings from diabetic mice treated with vehicle at 8 weeks (b), and in rings from diabetic mice treated with PJ34 (c). (d–f) Terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling, an indicator of DNA-strand breakage, in control rings (d), in rings from diabetic mice treated with vehicle at 8 weeks (e), and in rings from diabetic mice treated with PJ34 (f). (g–i) Immunohistochemical staining for poly(ADP-ribose), an indicator of PARP activation, in control rings (g), in rings from diabetic mice treated with vehicle at 8 weeks (h), and in rings from diabetic mice treated with PJ34 (i). Reproduced with permission from 33.