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. 2007 Dec 19;7:228. doi: 10.1186/1471-2407-7-228

Table 3.

Association between GST and EPHX1 genotypes and colorectal carcinomas and adenomas

	Controls	Carcinomas	OR (95% CI)^a	High-risk adenomas	OR (95% CI)^a	Low-risk adenomas	OR (95% CI)^a
Genotypes^b
*GSTM1*
Present	148	53	1 (ref)	84	1 (ref)	262	1 (ref)
Null	151	55	1.22 (0.65–2.30)	89	0.98 (0.63–1.52)	313	1.09 (0.80–1.49)

*GSTT1*
Present	262	93	1 (ref)	143	1 (ref)	488	1 (ref)
Null	37	15	1.37 (0.57–3.31)	30	1.36 (0.72–2.55)	87	0.99 (0.63–1.58)

GSTP1 Ile¹⁰⁵Val
Ile/Ile	119	51	1 (ref)	57	1 (ref)	240	1 (ref)
Ile/Val	140	50	0.82 (0.43–1.59)	90	1.27 (0.78–2.06)	272	1.00 (0.71–1.39)
Val/Val	40	7	0.38 (0.12–1.23)	26	1.29 (0.65–2.59)	63	0.79 (0.48–1.32)
Ile/Val + Val/Val	180	57	0.71 (0.38–1.32)	116	1.27 (0.80–2.02)	335	0.95 (0.69–1.31)
			P_trend= 0.13		P_trend= 0.35		P_trend= 0.49

EPHX1 Tyr¹¹³His
Tyr/Tyr	132	52	1 (ref)	75	1 (ref)	304	1 (ref)
Tyr/His	134	41	0.74 (0.37–1.47)	81	0.90 (0.57–1.44)	229	0.69 (0.50–0.97)
His/His	33	9	1.04 (0.33–3.21)	17	0.87 (0.40–1.88)	43	0.56 (0.32–0.99)
Tyr/His + His/His	167	50	0.78 (0.41–1.51)	98	0.90 (0.57–1.40)	272	0.67 (0.49–0.92)
			P_trend= 0.68		P_trend= 0.63		P_trend= 0.01

EPHX1 His¹³⁹Arg
His/His	190	56	1 (ref)	106	1 (ref)	347	1 (ref)
His/Arg	90	27	1.24 (0.60–2.57)	59	1.37 (0.85–2.21)	207	1.24 (0.88–1.74)
Arg/Arg	19	18	2.70 (0.96–7.58)	8	0.62 (0.23–1.70)	22	0.51 (0.25–1.06)
His/Arg + Arg/Arg	109	45	1.52 (0.79–2.93)	67	1.22 (0.77–1.91)	229	1.11 (0.80–1.53)
			P_trend= 0.09		P_trend= 0.82		P_trend= 0.83

^aAdjusted for age, gender, smoking dose, alcohol consumption, and the consumption of total meat and total fruit, berry and vegetable.

^bNumbers vary between analyzed genotypes due to missing samples and/or failed analysis.

ref: the genotype served as reference category.