Table 4.
Ratios of total meat to total fruit, berry and vegetable intake and the risk of colorectal carcinomas and adenomas by GST and EPHX1 genotypes
| OR (95% CI)a (Ncases/Ncontrols) | |||||||||
| Case group | Ratio of total meat to total fruit, berry and vegetable intakeb | GSTM1 | GSTP1 Ile105Val | EPHX1 Tyr113His | EPHX1 His139Arg | ||||
| Present | Null | Ile/Ile | Ile/Val+Val/Val | Tyr/Tyr | Tyr/His+His/His | His/His | His/Arg+Arg/Arg | ||
| Carcinomas | Q1 | 1 (ref) (11/39) | 1 (ref) (11/36) | 1 (ref) (7/32) | 1 (ref) (15/43) | 1 (ref) (10/33) | 1 (ref) (10/42) | 1 (ref) (9/51) | 1 (ref) (11/24) |
| Q2 | 0.84 (0.20–3.47) (11/33) | 2.99 (0.85–10.5) (18/40) | 2.01 (0.53–7.67) (16/27) | 1.52 (0.43–5.35) (13/46) | 3.28 (0.63–17.0) (17/29) | 1.65 (0.51–5.41) (12/44) | 4.67 (1.21–18.0) (17/48) | 0.69 (0.17–2.89) (12/25) | |
| Q3 | 1.05 (0.31–3.57) (19/43) | 2.39 (0.63–9.02) (18/32) | 1.85 (0.48–7.18) (15/31) | 1.22 (0.36–4.13) (22/44) | 2.59 (0.47–14.3) (18/36) | 1.34 (0.40–4.42) (17/39) | 2.78 (0.71–11.0) (20/45) | 0.63 (0.16–2.55) (14/30) | |
| Q4 | 0.49 (0.10–2.41) (12/33) | 0.78 (0.19–3.23) (8/42) | 1.61 (0.41–6.40) (13/28) | 0.11 (0.01–0.88) (7/47) | 0.70 (0.11–4.59) (7/33) | 0.63 (0.16–2.52) (11/42) | 0.90 (0.20–4.13) (10/46) | 0.34 (0.07–1.72) (8/29) | |
| Ptrend = 0.55 | Ptrend = 0.51 | Ptrend = 0.58 | Ptrend = 0.10 | Ptrend = 0.56 | Ptrend = 0.51 | Ptrend = 0.74 | Ptrend = 0.21 | ||
| High-risk Adenomas | Q1 | 1 (ref) (11/39) | 1 (ref) (11/36) | 1 (ref) (9/32) | 1 (ref) (13/43) | 1 (ref) (5/33) | 1 (ref) (17/42) | 1 (ref) (15/51) | 1 (ref) (7/24) |
| Q2 | 3.52 (1.26–9.85) (32/33) | 2.05 (0.80–5.26) (23/40) | 2.54 (0.85–7.54) (20/27) | 2.67 (1.09–6.51) (35/46) | 8.98 (2.54–31.8) (33/29) | 1.26 (0.52–3.05) (22/44) | 2.55 (1.05–6.24) (29/48) | 2.68 (0.88–8.19) (26/25) | |
| Q3 | 1.49 (0.53–4.21) (22/43) | 1.57 (0.59–4.20) (23/32) | 1.32 (0.42–4.16) (12/31) | 1.42 (0.57–3.56) (33/44) | 3.38 (0.90–12.75) (16/36) | 1.08(0.45–2.63) (29/39) | 2.00 (0.81–4.94) (31/45) | 0.93 (0.28–3.10) (14/30) | |
| Q4 | 1.83 (0.59–5.63) (19/33) | 1.91 (0.74–4.92) (32/42) | 1.89 (0.60–5.95) (16/28) | 1.68 (0.67–4.19) (35/47) | 3.65 (1.00–13.3) (21/33) | 1.44 (0.59–3.52) (30/42) | 1.94 (0.77–4.88) (31/46) | 1.65 (0.52–5.26) (20/29) | |
| Ptrend = 0.81 | Ptrend = 0.34 | Ptrend = 0.59 | Ptrend = 0.74 | Ptrend = 0.67 | Ptrend = 0.51 | Ptrend = 0.33 | Ptrend = 0.94 | ||
| Low-risk adenomas | Q1 | 1 (ref) (36/39) | 1 (ref) (54/36) | 1 (ref) (44/32) | 1 (ref) (46/43) | 1 (ref) (38/33) | 1 (ref) (52/42) | 1 (ref) (57/51) | 1 (ref) (33/24) |
| Q2 | 2.62 (1.28–5.35) (65/33) | 1.32 (0.70–2.48) (77/40) | 1.38 (0.67–2.83) (52/27) | 2.02 (1.08–3.77) (90/46) | 2.65 (1.28–5.46) (83/29) | 1.15 (0.61–2.14) (59/44) | 1.67 (0.94–2.98) (82/48) | 1.86 (0.83–4.15) (60/25) | |
| Q3 | 1.89 (0.96–3.74) (81/43) | 1.63 (0.85–3.12) (94/32) | 1.42 (0.71–2.85) (70/31) | 1.86 (1.00–3.47) (105/44) | 2.07 (1.02–4.20) (93/36) | 1.36 (0.73–2.54) (82/39) | 1.64 (0.91–2.93) (97/45) | 1.70 (0.78–3.71) (78/30) | |
| Q4 | 1.89 (0.90–3.98) (80/33) | 1.06 (0.55–2.04) (88/42) | 1.25 (0.60–2.65) (74/28) | 1.43 (0.75–2.73) (94/47) | 1.57 (0.74–3.35) (90/33) | 1.23 (0.65–2.33) (79/42) | 1.52 (0.83–2.79) (111/46) | 1.13 (0.50–2.56) (58/29) | |
| Ptrend = 0.25 | Ptrend = 0.80 | Ptrend = 0.55 | Ptrend = 0.48 | Ptrend = 0.49 | Ptrend = 0.46 | Ptrend = 0.22 | Ptrend = 0.98 | ||
a OR adjusted for age, gender, smoking dose and alcohol consumption.
b Quartiles of ratio of total meat to total fruit, berry and vegetable intake, per day: ≤ 0.19, >0.19 and ≤ 0.38, > 0.38 and ≤ 0.71, > 0.71.
ref: The combination served as a reference.