Table 1.
Axonal transport and function of NFT
| Neurotrophin | Site of synthesis | Transported to (neuronal population) | Transport | Function |
|---|---|---|---|---|
| NGF | Neocortex | ChAT-positive neurons of the nbM | Retrograde | Survival and maintenance of cholinergic, sensory and sympathetic neurons |
| Hippocampus | ChAT-positive neurons of the MS, VDB, HDB and sum | |||
| BDNF | Frontal cortex | Parietal, cingulate, infralimbic, orbital, perilimbic and occipital cortices, contralateral frontal cortex, nbM, hypothalamus, locus coeruleus, thalamus and HDB | Retrograde | Survival and maintenance (of dopaminergic neurons), synaptic plasticity (long-term potentiation, neuronal firing rate, neurotransmitter release and synaptic transmission) and metabolic effects |
| Occipital cortex | Retrosplenial, perirhinal, temporal, entorhinal and frontal cortices, Raphe nucleus, VDB (HDB), thalamus, lateral geniculate nucleus and hypothalamus | |||
| Hippocampus | Ipsi- and contralateral subfields of hippocampus, MS, sum and VDB (HDB) | |||
| Entorhinal cortex | Subiculum, CA1 and CA3 hippocampal subfields, amygdala, MS and VDB | |||
| Amygdala | Temporal, parietal and occipital, entorhinal, cingulate, infralimbic, insular piriform and perirhinal cortices, thalamus, dorsal Raphe, (pre)subiculum and CA1 subfields of hippocampus, medulla, HDB, hypothalamus, nbM and substantia nigra pars compacta | |||
| Striatum | Frontoparietal cortex, TH-positive neurons of the substantia nigra, Raphe and thalamus | |||
| Amygdala | Stria terminalis | Anterograde | ||
| Neocortex | Striatum | |||
| Dentate gyrus | CA3 subfield of hippocampus (through mossy fibers) | |||
| Pons | Amygdala | |||
| NT-3 | Hippocampus | MS, VDB, thalamus and sum of hypothalamus | Retrograde | Survival and maintenance |
HDB, horizontal limb of diagonal band of Broca; MS, medial septum; sum, supramammilary nucleus; TH, tyrosine hydroxylase; VDB, vertical limb of diagonal band of Broca.