Table 3.
Polymorphism in non-coding regions and haplotype association
| Polymorphism | Number of samples carrying a | |||
| DNA segment | position | Haplotype association | double peak * | single peak * |
| Intron 1 | -28G > C | DCe†, Dce, DcE | 14 | 9 |
| Intron 6 | 28C > T | RHDΨ ce ‡ | 4 | 3 |
| Exon 10, 3' UTR | 1347A > G | Dce | 6 | 1 |
| Intron 2 | 51C > T | Ccdes§ | 3 | 2 |
| Intron 2 | 135A > G | Ccdes§ | 3 | 2 |
| Intron 2 | -26G > A | Ccdes§ | 3 | 2 |
| Intron 2 | 36A > G | Dce or DAU-0ce | 1 | 0 |
| Intron 5 | 12G > A | DcE or RHD(384T > C)ce or Dce or RHD(384T > C)cE | 1 | 0 |
| Exon 10, 3' UTR | 1377G > A | Dce or DAU-0ce | 1 | 0 |
* The presence of a double peak in the electropherogram indicates another RHD allele in trans. A single peak may indicate the presence of an RHD deletion in trans, the homozygous presence of an allele with the given polymorphism, or – in case of intron 1 position -28 – the presence of Ccdes in trans. † -28G > C was present in all 13 DCe haplotypes, but only in 13 of 43 Dce and 1 of 8 DcE haplotypes. ‡ Present in all RHDΨ donors. § Present in all Ccdes donors.