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. 1999 Aug 17;96(17):9815–9820. doi: 10.1073/pnas.96.17.9815

Figure 5.

Figure 5

Effect of BV13 administration on vascular permeability in vivo. (A) BV13 (100 μg/mouse) induced a significant and time-dependent increase in Evans blue accumulation in heart (white columns) and lungs (striped columns). (B) BV13 increased vascular permeability in a concentration-dependent fashion. Different doses—10 μg/mouse (white columns), 50 μg/mouse (striped columns), or 100 μg/mouse (black columns) of BV13—were administered, and, after 7 hours, Evans blue extravasation was evaluated. (C) BV13 or BV14, 25 μg/mouse (gray columns) and 50 μg/mouse (stripped columns), was administered, and, after 7 hours, Evans blue leakage was measured. For the animals treated with BV13 and BV14, data are expressed as percentage increase in Evans blue content of the different organs in comparison to mice treated with the same concentration of the control mAb MEC 7.46 for the same time. Data are means ± SEM of at least five experiments, each performed in quadruplicates.