Figure 8.

Histological analysis of the effects of BV13 on heart and lungs. Morphological features of effects of BV13 on heart (A–C) and lungs (D–F). In the hearts of control animals, the characteristics of normal myocardium are evident (A). At 7 (B) and 9 hours (C) after BV13, there are interstitial edema and hemorrhage (open arrows) and interstitial accumulations of neutrophils (black arrows) and mononuclear cells (white arrows). The features of normal lung, including intact alveolar walls and venules, are apparent in control animals (D) whereas 9 hours after infusion of BV13, endothelial cell bleb formation is evident (open arrowheads) (E), together with intravascular neutrophils (black arrows), bleb formation involving small capillaries and epithelial cell (black arrowheads), and intravascular platelet aggregates (F). (Toluidine blue stain; 100×.)