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. 1997 Jul 1;110(1):45–58. doi: 10.1085/jgp.110.1.45

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Calmodulin-dependent enzymes regulate the GABA_B-BACLOFENR. This figure shows the effects of baclofen on barium currents in the presence of agents that inhibit calcium-calmodulin (Calmidazolium), phosphatases (Microcystin), and internal calcium release (Heparin and Ruthenium Red). (A) Baclofen (2) reduces the barium current. (B) Microcystin alone has little effect on this barium current (1) (recording from the same cell as in A), but the effect of baclofen was enhanced by microcystin (2). (C) Calmidazolium (1) (added to whole cell pipette) suppressed the effect of baclofen (2), while heparin and ruthenium red (both added to whole cell pipette) did not reduce the effect of baclofen. The left side of this figure contains examples from single ganglion cells while the right side of the figure charts the effects on the population of neurons examined.