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. 1997 Jul 1;110(1):45–58. doi: 10.1085/jgp.110.1.45

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The GABA_B-CACAR pathway is enhanced by nitric oxide. CACA's effect was enhanced when the retina was superfused with 8-bromo-cGMP or sodium nitroprusside. In each graph, the peak voltage-activated barium current was measured every 30 s and plotted. (A) While 50 μM 8-bromo-cGMP slightly reduced the barium current, 50 μM CACA in the presence of this second messenger analogue produced a much larger decrease in barium current than when applied alone (n = 22). (B) When a similar experiment was performed with the addition of 20 μM H-9, a cGMP kinase inhibitor, the effect of CACA was not enhanced (n = 10). (C) Addition of the impermeant 100 μM cGMP to the bath did not increase the CACA effect (n = 16). (D) When 300 μM sodium nitroprusside was added to the superfusate, the effect of CACA was enhanced (n = 6).