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. 1997 Jul 1;110(1):45–58. doi: 10.1085/jgp.110.1.45

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Baclofen reduces a voltage-activated barium current. The voltage was ramped from −120 to +60 mV in 1 s. The barium current was isolated and enhanced by replacing extracellular calcium with 10 mM barium and adding 40 mM TEA (equimolar replacement of NaCl). The top three panels show that 100 μM baclofen reduced the barium current, and the effect of baclofen was reversed by 1 mM 2-hydroxysaclofen. The lower set of panels confirms that 100 μM picrotoxin did not block the effect of baclofen.