Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1997 Jul 1;110(1):45–58. doi: 10.1085/jgp.110.1.45

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

The GABA_B-BACLOFENR suppresses a ω-conotoxin–GVIA-sensitive calcium channel. The upper left panel in A shows that baclofen reversibly reduces barium current (1 = control; 2 = baclofen; 3 = recovery). The adjacent panel in A, from the same cell, illustrates that 50 μM nimodipine (2) reduces the control barium current (1), but 50 μM baclofen in the presence of nimodipine (3) further reduces the current. A summary of the results is charted in the upper right panel. In total 19 neurons were tested, but in only 14 of the 19 was baclofen alone tested. The bottom row illustrates similar studies performed using ω-con-otoxin-GVIA (ω-CgTx) (2), an N-type calcium channel blocker, followed by application of 50 μM baclofen in the presence of ω-CgTx (3). A summary of data on eight neurons appears in lower right panel. Seven of the eight were tested with baclofen alone.