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. 1997 Sep 1;110(3):313–325. doi: 10.1085/jgp.110.3.313

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Effect of channel blockers. (A) Current measured during 1-s voltage step to +120 mV in the absence and presence of 250 μM niflumic acid. (B) Same traces as in A, but rescaled to illustrate the higher inactivation rate in the presence of the channel blocker. (C) Steady state inactivation curves in the absence and presence of 250 μM niflumic acid. Eq. 2 fitted to the data points yielded values for V _1/2 of 75 and 62 mV and for k _V of 14.1 and 12.6 mV in the absence and presence of 250 μM niflumic acid. (D) Voltage and blockers dependence of the relative amplitude of the fast inactivating component. (E) Time constants for the recovery from inactivation in the absence and presence of 250 μM niflumic acid. (F) Effect of 250 μM niflumic acid on the recovery from inactivation after 500 ms. Symbols in B–F : •, control and ○, 250 μM niflumic acid.