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. 1997 Oct 1;110(4):467–483. doi: 10.1085/jgp.110.4.467

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The pH_i decrease elicited by removing external Na⁺ in CO₂/HCO₃ ⁻ does not require external Cl⁻. In the presence of 5% CO₂/17 mM HCO₃ ⁻ (a–i), the cell was exposed twice to a solution in which Li⁺ replaced external Na⁺ (cd and fg). During the indicated period, cyclamate replaced external Cl⁻ (e–h). As shown in the inset, a hypothetical cell possessing a Na⁺-driven Cl-HCO₃ exchanger should have exhibited a pH_i decrease upon removing external Na⁺, and this pH_i decrease should have required external Cl⁻. The arrows point to the initial pH_i decrease elicited by removing external Cl⁻.