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A series of “snapshots” of a 60-channel couplon at 1-ms intervals during a depolarization to −50 mV. A coincident opening of two neighboring V channels triggers C channel openings, which then propagate as a wave along the length of the couplon until stopped by random inactivation events. Solid diamond, closed V channel; solid square, closed C channel; checkered diamond, open V channel; open square, open C channel; gray circle, inactivated C channel.
