Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1997 Oct 1;110(4):415–440. doi: 10.1085/jgp.110.4.415

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Release computations incorporating the effects of SR depletion and global cytosolic calcium. (A) Global cytosolic [Ca²⁺] during depolarizations to two voltages. (B) Ca²⁺ release current, showing at the higher voltage a slow decaying phase, due to SR depletion during the pulse. (C) SR calcium content during the two pulses, expressed as equivalent concentration in accessible myoplasmic water. (D) Release corrected for depletion; i.e., divided by the fraction of SR calcium content remaining. The qualitative features of the corrected release are similar to the results of the model when the global calcium pool is neglected (e.g., Fig. 1).