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. 1997 Oct 1;110(4):379–389. doi: 10.1085/jgp.110.4.379

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Ca-dependent inactivation is normal in α_1C−3′del, CSk1, and CSk8. (A) Representative Ca (top) and Ba (bottom) currents mediated by α_1C−3′del, a deletion mutant of α_1C lacking amino acid residues 1813–2166 from the COOH terminus. Test pulses from 0 to +40 mV (Ca) and −10 to +60 mV (Ba). Files 95929002, 95929006. C = 42 pF. R_S = 3.8 MΩ. (B) Representative Ca and Ba currents mediated by CSk1, a chimera in which the NH₂ terminus of α_1C was replaced by the corresponding region from α_1S. Test pulses from 0 to +40 mV (Ca) and 0 to +60 mV (Ba). Files 95D01016, 95D01018. C = 21 pF. R_S = 6.3 MΩ. (C) Representative Ca and Ba currents mediated by chimera CSk8, in which the III–IV loop of α_1C was replaced by the corresponding region from α_1S. Test pulses from +30 to +50 mV (Ca) and +20 to +40 mV (Ba). Files 96118045, 96118053. C = 15 pF. R_S = 4.9 MΩ. Experiments summarized in this figure were done using the TEACl-based external solution.