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. 1997 Oct 1;110(4):379–389. doi: 10.1085/jgp.110.4.379

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CSk4 lacks Ca-dependent inactivation. (A) Representative Ca currents mediated by CSk4, in which the distal 80% of the COOH terminus of α_1C has been replaced by the corresponding region from α_1S. File 97501003. C = 26 pF. R_S = 3.6 MΩ. (B) Representative Ba currents mediated by CSk4. File 97501008. Same cell as in A. For the illustrated currents, inactivation appears to be slightly slower for Ba than for Ca currents, but this is only apparent: the Ba currents are larger and therefore less contaminated by outward currents. (C) I–V relations for CSk4 currents. Each point represents the mean (±SEM) of four different cells. (D) Voltage dependence of fast time constants for inactivation of CSk4 currents. Each point represents the mean (±SEM) of four different cells. Experiments summarized in this figure were done using the NaCl-based external solution.