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. 1997 Nov 1;110(5):515–528. doi: 10.1085/jgp.110.5.515

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Modulation of 8-Br-cGMP-dependent activation of current in membrane patches detached from cone outer segments. (top) Currents measured at room temperature in the same membrane patch before (A) and after (B) exposure to the EDTA/ EGTA solution. Currents were activated with a voltage step from 0 to −40 mV in the presence of 20 μM Ca⁺⁺ and 100 μM Mg⁺⁺ and 8-Br-cGMP at 0, 5, 10 (arrow), 20, and 500 μM. C illustrates the dependence of current amplitude on 8-Br-cGMP before and after exposure to the EDTA/ EGTA solution. The continuous line is the best fit to the data of the Hill equation (Eq. 1). K _1/2 = 22 μM and n = 2.55 before exposure to the EDTA/EGTA solution, and K _1/2 = 15.5 μM and n = 1.66 afterwards.

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