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Serial 19F spectra of a subcutaneous HT29/yCD tumor. Acquisition began 20 min after i.p. administration of 1 g/kg 5-FC. Each spectrum is the average of 277 free induction decays collected in a 20-min interval. The time from 5-FC injection to the beginning of the acquisition interval are shown beside the spectra. The chemical shift assignments (in ppm) of the metabolite peaks relative to NaF are: FNuc, −45.0; 5-FC, −48.5; and 5-FU, −49.6.
