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. 1997 Dec 1;110(6):727–740. doi: 10.1085/jgp.110.6.727

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Representative experiment (of a group of nine tissues) of the action of basolateral La³⁺ (2 μM as La(NO₃)₃) on the TJ seal, as evaluated by TER. The urinary bladders were short-circuited and bathed on the apical side by 75 mM KCl and on the basolateral side by NaCl HEPES Ringer's solution. (A) TER decreases in response to addition of basolateral La³⁺ (+La_bl) and fully recovers upon La³⁺ removal (−La_bl). (B) Control experiment performed in the same tissue of the effect of basolateral Ca²⁺ withdrawal and subsequent reintroduction, showing the similarity between the responses to La³⁺ addition and Ca²⁺ removal. The vertical deflections of SCC, caused by pulses of ±1 mV in the clamping potential, are proportional to the overall tissue electrical conductance (G), where G = 1/TER.