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. 1997 Dec 1;110(6):727–740. doi: 10.1085/jgp.110.6.727

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Representative experiments (in two groups of six tissues) of the action of apical La³⁺ on tissue response to manipulation of basolateral Ca²⁺. (A) Addition of La³⁺ (2 μM as La(NO₃)₃) to the apical solution (+La_ap) has no effect whatever upon TER. Its subsequent removal (−La_ap) renders the tissue responsive to the removal (−Ca_bl) and reintroduction (+Ca_bl) of basolateral Ca²⁺, as in control tissues not exposed to apical La³⁺. (B) Addition of La³⁺ (2 μM as La(NO₃)₃) to the apical solution (+La_ap) during TER decrease caused by removal of basolateral Ca²⁺ (−Ca_bl) terminates the process of TER decrease and blocks TER recovery induced by reintroduction of basolateral Ca²⁺ (+Ca_bl). The vertical deflections of the SCC, caused by pulses of ±10 mV in the clamping potential, are proportional to the overall tissue electrical conductance (G), where G = 1/TER.