Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1998 Jul 1;112(1):55–69. doi: 10.1085/jgp.112.1.55

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Schematic representation of the reversible interaction of 21-amino-9α-hydroxy-ryanodine with its site on the channel. On binding, the ryanoid induces a modified conductance state with high open probability. With the ryanoid bound, the channel can close but cannot enter the normal open state. When 21-amino-9α-hydroxy-ryanodine dissociates from its site, channel gating and ion handling return to normal. Dwell times in the unmodified and modified states are monitored using the pattern recognition program described in materials and methods. The probability of the channel being in the modified state (P _mod) is then calculated for the entire 6-min recording as described in the text.