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. 1998 Jul 1;112(1):55–69. doi: 10.1085/jgp.112.1.55

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The relationship between P _mod and holding potential. The probability of occurrence of the channel in the modified conductance state was determined as described in materials and methods in 6-min recordings with 500 nM 21-amino-9α-hydroxy-ryanodine in the solution at the cytosolic face of the channel. Each point is the mean ± SEM of five to seven experiments. Where not visible, error bars are included within the symbol. The solid line is the best fit Boltzmann distribution obtained by nonlinear regression with the parameters quoted in the text.