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. 1998 Jul 1;112(1):55–69. doi: 10.1085/jgp.112.1.55

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The relationship between P _mod and P _o. P _mod was determined by monitoring dwell times in the unmodified and modified conductance states in 18 six-min recordings, and P _o was determined during the unmodified sections of each recording. P _o was altered by varying the concentration of EMD 41000 at the cytosolic face of the channel. 700 nM 21-amino-9α-hydroxy-ryanodine was present in the solution at the cytosolic face of the channel and the holding potential was +40 mV. The curve has no theoretical significance.