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Amiloride Blocking and Unblocking Rate Constants for αβ, αβT and αγT
| Channel | [amil] | K ON (−40) | K OFF (−40) | K d (−40) | K d (0) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| αβ | 1.0 μM | 29 μM−1 s−1 | 44 s−1 | 1.5 μM | 2.7 μM | |||||
| αβT | 1.0 μM | 39 μM−1 s−1 | 39 s−1 | 1.0 μM | 1.7 μM | |||||
| αγT | 0.1 μM | 66 μM−1 s−1 | 3 s−1 | 0.05 μM | ND |
K ON, K OFF, and K d values for amiloride block of αβ, αβT, and αγT channels. Note that the units for the K ON values have been converted to μM−1 s−1 from 105 M−1 s−1 as given in Fig. 7.
