Figure 3.

Kinetics of Zn²⁺ inhibition and recovery are temperature sensitive. (A) Inhibition of ClC-0 by 10 μM Zn²⁺ at three different temperatures. (B) Inhibition of Shaker K⁺ channels by 20 mM TEA. The membrane potential was held at −80 mV and a 30-ms voltage pulse to +30 mV was given every second. Dotted lines in A and B represent zero-current level. (C) Comparison of the time constants of Zn²⁺ inhibition of ClC-0 (○ and ▵) with those of TEA inhibition of the Shaker K⁺ channel (• and ▴). Circles, time constants of current inhibition; triangles, time constants of current recovery (n = 4–5).