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. 1999 Sep 1;114(3):429–444. doi: 10.1085/jgp.114.3.429

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Reversal potential measurements of GAT1 current. (A) GAT1 transport current with all three substrates on both membrane sides was defined by pipette perfusion of NO-711 (13 μM) to the extracellular side. The pipette (extracellular) solution contained 0.4 mM GABA and 120 mM NaCl; the bath (cytoplasmic) solution contained 2 mM GABA, 60 mM Na⁺, and 6 mM Cl⁻. (B) NO-711_o–defined reversal potentials are plotted against the theoretical values for various conditions listed below the graph. All reversal potentials were measured at 35°C. The dotted line represents the values predicted for perfect 2Na⁺:1Cl⁻:1GABA stoichiometry.