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. 1999 Oct 1;114(4):477–490. doi: 10.1085/jgp.114.4.477

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Single-channel currents and corresponding amplitude histograms in a patch containing at least three CNG channels at 70 (left) and 7 (right) μM cGMP. The patch was held at +50 mV. The individual traces of 500-ms duration were recorded in intervals of 1 s. The final cut-off frequency was 1 kHz. The amplitude histograms were formed with the variance-mean technique with a window width of 280 μs (seven sampling points). The distributions were fitted with sums of either four or two Gaussian functions. The respective single-channel currents i and standard deviations σ are indicated. At 70 μM cGMP, the amplitude histograms were formed from consecutive traces, whereas at 7 μM cGMP only nonempty traces were used. Significant sublevel openings were not present.