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. 1999 Oct 1;114(4):477–490. doi: 10.1085/jgp.114.4.477

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Open-time histograms at 7 and 700 μM cGMP and +50 and −50 mV each. The data were obtained from a multichannel patch at 7 μM cGMP and a single-channel patch at 700 μM cGMP. The distributions were fitted with sums of two exponentials yielding the indicated contributions A_n and open-time constants τ_n. The combination of high [cGMP] and positive voltage caused a dramatic prolongation of both time constants. Filter, 2 kHz.