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. 1999 Oct 1;114(4):477–490. doi: 10.1085/jgp.114.4.477

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Voltage dependence of macroscopic currents through cGMP-gated channels at different [cGMP]. Recordings at 20 and 70 μM cGMP were obtained from one patch and at 700 μM and 7 mM cGMP from another patch. The membrane voltage V_m was stepped from −100 mV to another voltage between −80 and +100 mV in 20-mV increments. The duration and frequency of pulses were either 50 ms and 2 Hz (20 and 70 μM cGMP) or 4 ms and 10 Hz (700 μM and 7 mM cGMP), respectively. Traces represent the average of 10–20 consecutive current recordings. Each trace was corrected for capacitive and small leakage currents by subtracting a current that was averaged from 5–10 control traces recorded in the absence of cGMP.