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. 1999 Oct 1;114(4):525–533. doi: 10.1085/jgp.114.4.525

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Concentration-dependent effects of NPPB on swelling-induced ATP release detected by the luminometric assay and on whole-cell volume-sensitive outwardly rectifying Cl⁻ currents. (A) Concentration–inhibition curves of NPPB for ATP release under hypotonic (•) and isotonic (○) conditions. (Symbols) Means ± SEM; n = 10–26 experiments. Inhibitory effects of 10, 20, and 30 μM NPPB on hypotonic ATP release were statistically significant at P = 0.0038, 0.0006, and 0.0003, respectively, and those of 10 and 30 μM NPPB on isotonic ATP release were at P = 0.0017 and 0.0195, respectively. (B) Logarithmic concentration–inhibition curves of NPPB for swelling-induced ATP release (□) and VSOR Cl⁻ currents at −60 mV (▪). (Symbols) Means ± SEM; n = 4–11 experiments.