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. 2000 Nov 1;116(5):697–720. doi: 10.1085/jgp.116.5.697

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Comparison of the decay time courses of AP-induced Ca²⁺ transients and the accompanying I_AHPs and effects of ryanodine and thapsigargin on them. (A) Effects of ryanodine on the Ca²⁺ transient within 2 μm from the plasma membrane (a) and the corresponding I_AHP (b and c) induced by 10 spikes. Gray and black traces are the records before and 10 min after the application of ryanodine (10 μM). I_AHPs are shown in different time scales (b and c). The time scale of b is the same as that of the Ca²⁺ transient in a. Each of smooth lines on the Ca²⁺ transients and I_AHPs shows the result of double exponential fitting to the decay phase of each trace after the end of current stimuli. (B) Effects of thapsigargin (1 μM) on the Ca²⁺ transient (a) and the I_AHP (b and c) induced by 10 spikes. Other explanations are the same as those in A.