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. 2000 Nov 1;116(5):697–720. doi: 10.1085/jgp.116.5.697

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Effects of thapsigargin on AP-evoked Ca²⁺ transients. (A–D) The inward spreads and time courses of Ca²⁺ transients induced by a single AP (a) and five APs (b) in the presence of thapsigargin (2 μM). Explanations are the same as those in Fig. 3B–E except that the data were taken in the presence of thapsigargin. Note that the basal [Ca²⁺]_i increased by thapsigargin corresponds to cold colors for the clearer demonstration of Ca²⁺ transients. However, the difference in the [Ca²⁺]_i level from the control is shown in the scaling of the color cord.