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. 2000 Nov 1;116(5):721–734. doi: 10.1085/jgp.116.5.721

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Regulation alters occupancy of the long-lived closed state. Single KCNKØ channels were studied as in Fig. 2. (A) Open time histogram obtained from 17 s of single KCNKØ channel recordings filtered at 3 kHz under control conditions. (B) Closed time histograms under control conditions; (left) obtained from 17 s of single KCNKØ channel recordings filtered at 3 kHz; (right) obtained from 41 min of recordings of single KCNKØ channels filtered at 100 Hz. Four channel records were combined for this analysis. (C) Open time histogram obtained from 22 s of single KCNKØ channel recordings filtered at 3 kHz in the presence of PMA. (D) Closed time histograms in the presence of PMA: (left) obtained from 22 s of single KCNKØ channel recordings filtered at 3 kHz; and (right) obtained from 54 min of recordings of single KCNKØ channels filtered at 100 Hz. Four channel records were combined for this analysis. (E) Four KCNKØ channels were recorded in an on-cell patch at 60 mV with PMA in the bath and then in staurosporine as indicated. Data were sampled at 940 Hz and filtered at 20 Hz.