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A negatively charged residue at position 418 is necessary for normal channel gating. (A) Currents recorded in cells transfected with the indicated channel types. In all cases, 100-ms pulses were applied from −80 to +20 mV. (B) Sequence alignment of the region between the carboxyl end of membrane-spanning segment S5 and the pore helix in several types of K+ channels. In a box is glutamate 418 of Shaker, conserved at the same position in all the channels indicated.
