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. 2000 Aug 1;116(2):181–190. doi: 10.1085/jgp.116.2.181

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Modulation by extracellular K⁺ of C-type inactivation and closing time courses in E418Q channels. (A, left) Scaled current traces generated by pulses to +20 mV; (right) inactivation time constant (τ_i, ordinate) as a function of extracellular [K⁺] (abscissa). Data points are the mean and the vertical bars are the standard deviation of measurements done in six cells. (B, left) Scaled recordings of tail currents illustrating the deactivation time course at the indicated membrane potentials (−50, −70, and −90 mV) of wild-type (E418E) and E418Q channels with 30 mM external K⁺. (Right) Closing time constant (expressed in the ordinate as the inverse of the deactivation rate constant) of the two channel types as a function of the membrane potential (abscissa). Data points are the mean and the vertical bars are the standard deviation of measurements done in eight (E418E) and four (E418Q) cells.