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. 2000 Aug 1;116(2):147–162. doi: 10.1085/jgp.116.2.147

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Response of oCNG channels expressed in an HEK-AC8 cell to the photolysis of caged cAMP. (A) Photolysis of NPE-cAMP is indicated by flash artifacts, V_m = −50 mV. Data are from one cell; the external solution contained either 0.1 or 10 mM MgCl₂. No photolysis-induced currents were observed when the cell was bathed in 10 mM MgCl₂. Zero current is indicated by the dotted line. The basal current was due to 20 μM cAMP in the pipette solution and a small amount of leak (see 10 mM MgCl₂ trace). (B) No response to the photolysis of caged cAMP was observed in cells not expressing oCNG channels (uninfected) or in oCNG channel–expressing cells with 1 mM cAMP added to the pipette solution.