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. 2001 Sep 1;118(3):291–302. doi: 10.1085/jgp.118.3.291

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Effects of the neutralization of each of the positive charges of the IIS4 segment of rat brain Na_v1.2a sodium channel. Voltage dependence of activation (A) and inactivation (B) for wild-type Na_v1.2a, R850Q, R853Q, R856Q, K859Q, and K862Q. Conductance-voltage curves were determined as described in materials and methods . Inactivation curves were determined using 150-ms-long prepulses to the indicated potentials followed by test pulses to 0 mV.