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. 2001 Sep 1;118(3):291–302. doi: 10.1085/jgp.118.3.291

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Activity of Css IV on MTS-modified R850C and R853C sodium channels. Conductance-voltage relationships for R850C-MTSET (A and B) or R853C-MTSEA (C and D) in the presence of 200 nM Css IV without (A and C) or with a +50 mV, 1–ms prepulse preceding the test pulse (B and D). Data were fit with Boltzmann relationships with (A) V_1/2 = −25.6 ± 0.8 mV, k = 10.2 mV for R850C-Css IV (n = 4) and −46.3 ± 0.6 mV, k = 9.8 mV for R850C-MTSET-Css IV; (B) with V_1/2 = −54.3 ± 0.9 mV, k = 12.3 mV for R850C-Css IV (n = 6), and −57.1 ± 0.9 mV, k = 9.6 mV for R850C-MTSET-Css IV (n = 4); (C) V_1/2 = −44.8 ± 0.5 mV, k = 9.7 mV for R853C-Css IV (n = 7), −20.1 ± 0.7 mV, k = 7.1 mV for R853C-MTSEA-Css IV (n = 3); (D) V_1/2 = −49.0 ± 0.7 mV, k = 8.8 mV for R853C-Css IV (n = 6); −28.0 ± 1.01 mV, k = 12.6 mV for R853C-MTSEA-Css IV (n = 3). The toxin-free curves in A and C are repeated from Fig. 3.